Use the basic search feature: The main CareerBuilder search box is front and center on the main page. You'll want to come up with few keywords that pertain to the occupation that you're looking for, such as "technology", along with a specific city and state or zip code. From these humble beginnings, you'll be able to narrow the job posted timeframe, most relevant jobs, and expand your occupational options.
Explore the site map: The first thing I like to hunt for when visiting a new site is the site map, and you'll want to visit CareerBuilder's. This is where you can get a quick overview of everything they have to offer in one quick glance.
Search by specific category: CareerBuilder has many categories that you can browse around in: By Company, By Industry, En Espanol, International Jobs, Canada, or view all the occupational categories in one place at the site map.
Set up a job alert: You don't have to visit CareerBuilder every single day - you can set up a job alert to have your job searches emailed to you. Make them as targeted to your job searches as you possibly can for better success.
Try the advanced search: CareerBuilder has an impressive advanced search page; you can select from a dozen different search criteria, as well as exclude information you don't want in your job search.
As you can see, CareerBuilder offers quite a few different search options. For more job search engines, check out the Top Ten Job Search Engines on the Web, and be sure to visit the excellent About Job Search guidesite.